ORIGINAL ARTICLE
Introducing a new sedation policy in a large district general
hospital: before and after cohort analysis
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1
Critical Care Directorate, Aneurin Bevan University Health Board, Royal Gwent Hospital, Cardiff Road,
Newport, Gwent, NP20 2UB, United Kingdom
2
Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine,
Cardiff University, Heath Park Campus, Cardiff, CF14 4XN, United Kingdom
Publication date: 2019-09-12
Anaesthesiol Intensive Ther 2019;51(1):4-10
KEYWORDS
ABSTRACT
Background:
The management of pain, agitation and sedation for ventilated patients who are admitted to intensive care
is an essential part of their care. The introduction of sedation protocols is associated with improved patient outcomes.
Methods:
We conducted an observational cohort study among mechanically ventilated patients in a 16-bed ICU
over a two-year period. We retrospectively examined data from two patient populations, namely those before and
after the introduction of a new sedation protocol in July 2015. The primary outcome was the duration of mechanical
ventilation in both groups.
Results:
After the implementation of the new sedation protocol, there was a significant decrease in the mean duration
of mechanical ventilation (1.45 days). Furthermore, we observed a non-significant reduction in the mean duration
of ICU stay.
Conclusion:
The new protocol was associated with outcome improvements including: decreased mean duration
of mechanical ventilation and a reduced number of ventilated days; and increased patient throughput with a slight
increase in the length of vasopressor support. Moreover, the use of a structure-process-outcome model of quality
improvement was associated with significant improvements in process measures of quality.