ORIGINAL ARTICLE
Cost-effectiveness of home mechanical ventilation in children
living in a developing country
More details
Hide details
1
Pediatric Respiratory and Sleep Medicine Research Center, Children’s Medical Center, Tehran University
of Medical Sciences, Tehran, Iran
2
Students’ Research Committee, School of Public Health, Shahid Beheshti University of Medical Sciences,
Tehran, Iran
3
Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran
4
Department of Pediatric Pulmonology, Child Growth and Development Research Center, Research Institute
for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
5
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
6
Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran; and Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
7
Department of Epidemiology, Qom University of Medical Sciences, Qom, Iran
Publication date: 2019-09-12
Anaesthesiol Intensive Ther 2019;51(1):35-40
KEYWORDS
ABSTRACT
Background:
Home mechanical ventilation is a promising option for children requiring long-term mechanically assisted
ventilation, despite data on the cost-effectiveness of this approach being limited. The aim of the study was to investigate
the cost-effectiveness of home mechanical ventilation in children requiring long-term mechanically assisted ventilation
Methods:
A retrospective cohort study was conducted on 67 children (32 girls, 47.7%) requiring mechanically assisted
ventilation. The underlying diseases of the children concerned were as follows: congenital airway malformations in
24; cystic fibrosis in 4; severe laryngomalacia in 16; polyneuropathy syndrome in 6; mitochondrial myopathy in 5;
hypoxic ischaemic encephalopathy in 6; and cerebral palsy in 2. The children were admitted to paediatric intensive
care units (ICU) for 2 weeks. After discharge, they were placed on home mechanical ventilation and were followed-up
for 1 year. Data on the daily costs of hospital stay at the ICU, re-hospitalisations, weaning, educational performance
and muscle strength were gathered.
Results:
The mean age of children at time of initiation of mechanically assisted ventilation was 5.2 ± 4.9 years (ranging
from 2 months to 15 years). The mean number of re-hospitalisations was 3.6 ± 4.9 times with a mean duration of
53.2 ± 44.9 days. Of the children on mechanical ventilation, 1 was attending school, 2 had been weaned, and 21 had
experienced improvement in muscle strength. No fatal or serious complications were observed while the children were
on home mechanical ventilation. The median (IQR) cost of daily ICU stay admission was USD 3,625.0 (USD 7,075.0),
while the median daily cost of home mechanical ventilation was USD 1,402.0 (USD 1,044.2) (P < 0.001).
Conclusions:
Home mechanical ventilation is more cost-effective compared with ICU stay for only mechanically
assisted ventilation.